Maternal serum ferritin levels in small for gestational age pregnancies. Perinatoloji Dergisi 2015;23(3):S62 - S63
- Department of Obstetrics and Gynecology, Divısion of Perinatology, Faculty of Medicine, Süleyman Demirel University, Isparta
- Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Traınıng and Research Hospital, Ankara
Mehmet Özgür Akkurt, Department of Obstetrics and Gynecology, Divısion of Perinatology, Faculty of Medicine, Süleyman Demirel University, Isparta,
Gönderilme Tarihi: 30 Ağustos 2015
Son Revizyon Tarihi: 30 Ağustos 2015
Kabul Edilme Tarihi: 01 Eylül 2015
Erken Baskı Tarihi: 01 Ekim 2015
Yayınlanma Tarihi: 01 Ekim 2015
Çıkar çakışması bulunmadığı belirtilmiştir.
We sought to compare maternal and infant ferritin levels across pregnancies with fetal growth delay including constitutional and pathological small for gestational age (c-SGA and p-FGR) compared to appropriate for gestational age (AGA).
A case-control study was conducted in term pregnant women and their neonates throughout a 3-year-period. Three groups were enrolled: AGA, c-SGA (birth weight <10 p for gestational age with no placental insufficiency findings), and p-FGR (birth weight <5p for gestational age accompanied by abnormal umbilical artery Doppler waveforms and/or oligohydramnios). Receiver operating characteristic (ROC) curves were used to determine the threshold for maternal serum ferritin in each group. Sensitivity, specificity, accuracy, positive and negative predictive values (PPV and NPV) plus positive and negative likelihood ratios (LR+ and LR-) were calculated following the determination of the presumed thresholds.
A total of 131 pregnancies with AGA (38%), c-SGA (38%), and p-FGR (24%) were enrolled. The mean maternal serum ferritin level was higher in the p-FGR group than in the AGA group (59 microg/l versus 32.5 microg/l, p<0.001). A maternal ferritin cut-off of 48 microg/l was found to be optimal for distinguishing between p-FGR and AGA with a sensitivity of 67.7%, specificity of 92%, PPV of 84%, NPV of 82%, diagnostic accuracy of 82.7%, LR+ of 8 and LR- of 0.3, respectively.
Maternal serum ferritin levels may differ in pregnancies with pathological SGA. The role of maternal serum ferritin measurements as a clinical tool for distinguishing different forms of SGA warrants further investigation.