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Dergi Kimliği

Online ISSN (İngilizce)
1305-3124

Basılı ISSN (Türkçe)
1300-5251

Online ISSN (Türkçe)
1305-3132

Kuruluş
1993

Editör
Cihat Şen

Yardımcı Editörler
Murat Yayla, Oluş Api

Changes in copper, zinc, copper/zinc ratio, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia

Murat Bakacak, Salih Serin, Metin Kılınç, Fazıl Avcı, Önder Ercan, Bülent Köstü, Hakan Kıran, Gürkan Kıran

Künye

Changes in copper, zinc, copper/zinc ratio, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia. Perinatoloji Dergisi 2015;23(3):S72 DOI: 10.2399/prn.15.S001084

Yazar Bilgileri

Murat Bakacak1,
Salih Serin2,
Metin Kılınç1,
Fazıl Avcı3,
Önder Ercan1,
Bülent Köstü1,
Hakan Kıran1,
Gürkan Kıran1

  1. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Kahramanmaraş
  2. Tatvan Devlet Hastanesi, Bitlis
  3. Patnos Devlet Hastanesi, Ağrı
Yayın Geçmişi

Gönderilme Tarihi: 30 Ağustos 2015

Son Revizyon Tarihi: 30 Ağustos 2015

Kabul Edilme Tarihi: 01 Eylül 2015

Erken Baskı Tarihi: 01 Ekim 2015

Yayınlanma Tarihi: 01 Ekim 2015

Çıkar Çakışması

Çıkar çakışması bulunmadığı belirtilmiştir.

Amaç
Preeclampsia (PE) is a hypertensive disorder of pregnancy which is estimated to occur in 2% to 8% of pregnancies. Numerous studies have investigated the aetiology and pathophysiology of preeclampsia. However, the pathophysiology of preeclampsia remains poorly understood. The aim of the current study was to determine the levels of MDA and SOD, concentrations of Cu, Zn and the Cu/Zn ratio in pregnant females with and without PE and in non-pregnant females of reproductive age to investigate a possible correlation between these parameters and foetal birth weight.
Yöntem 
Forty-two non-pregnant women (NP), 40 healthy pregnant women (HP) and 38 pre-eclamptic pregnant (PE) women were included in this study. Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), Cu and Zn and Cu/Zn ratios were studied in these cases. In addition, correlations of the serum levels of Cu, Zn, MDA, SOD and Cu/Zn rate with foetal birth weights were examined.
Bulgular
Cu, MDA levels and Cu/Zn ratio were significantly higher in the PE group than in the HP and NP groups, and significantly higher in the HP than in the NP group (p<.001 and p<.001; respectively). Serum Zn and SOD levels were significantly lower in the PE group compared with those in the HP and NP groups, and significantly lower in the HP than in the NP group (p<.001 and p<.001; respectively). When a possible correlation was investigated between the serum levels of Cu, Zn, MDA, SOD and Cu/Zn ratio, a statistically significant negative correlation was found only between increased rates of Cu/Zn and foetal birth weight in the PE group (r=-0.433, p<.001).
Sonuç
Increased lipid peroxidation and an impaired antioxidant defence mechanism as well as the concentration of trace elements such as Cu and Zn, and a possible correlation between those parameters may be associated at least partly with the pathogenesis of pre-eclampsia. In addition, the Cu/Zn ratio may be a parameter which can be used in the prediction of vascular complications of PE. 
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