Changes in copper, zinc, copper/zinc ratio, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia. Perinatoloji Dergisi 2015;23(3):S72
- Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Kahramanmaraş
- Tatvan Devlet Hastanesi, Bitlis
- Patnos Devlet Hastanesi, Ağrı
Gönderilme Tarihi: 30 Ağustos 2015
Son Revizyon Tarihi: 30 Ağustos 2015
Kabul Edilme Tarihi: 01 Eylül 2015
Erken Baskı Tarihi: 01 Ekim 2015
Yayınlanma Tarihi: 01 Ekim 2015
Çıkar çakışması bulunmadığı belirtilmiştir.
Preeclampsia (PE) is a hypertensive disorder of pregnancy which is estimated to occur in 2% to 8% of pregnancies. Numerous studies have investigated the aetiology and pathophysiology of preeclampsia. However, the pathophysiology of preeclampsia remains poorly understood. The aim of the current study was to determine the levels of MDA and SOD, concentrations of Cu, Zn and the Cu/Zn ratio in pregnant females with and without PE and in non-pregnant females of reproductive age to investigate a possible correlation between these parameters and foetal birth weight.
Forty-two non-pregnant women (NP), 40 healthy pregnant women (HP) and 38 pre-eclamptic pregnant (PE) women were included in this study. Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), Cu and Zn and Cu/Zn ratios were studied in these cases. In addition, correlations of the serum levels of Cu, Zn, MDA, SOD and Cu/Zn rate with foetal birth weights were examined.
Cu, MDA levels and Cu/Zn ratio were significantly higher in the PE group than in the HP and NP groups, and significantly higher in the HP than in the NP group (p<.001 and p<.001; respectively). Serum Zn and SOD levels were significantly lower in the PE group compared with those in the HP and NP groups, and significantly lower in the HP than in the NP group (p<.001 and p<.001; respectively). When a possible correlation was investigated between the serum levels of Cu, Zn, MDA, SOD and Cu/Zn ratio, a statistically significant negative correlation was found only between increased rates of Cu/Zn and foetal birth weight in the PE group (r=-0.433, p<.001).
Increased lipid peroxidation and an impaired antioxidant defence mechanism as well as the concentration of trace elements such as Cu and Zn, and a possible correlation between those parameters may be associated at least partly with the pathogenesis of pre-eclampsia. In addition, the Cu/Zn ratio may be a parameter which can be used in the prediction of vascular complications of PE.