Changes in copper, zinc, copper/zinc ratio, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia

Murat Bakacak, Salih Serin, Metin Kılınç, Fazıl Avcı, Önder Ercan, Bülent Köstü, Hakan Kıran, Gürkan Kıran

Bilgiler
Özet

Künye

Changes in copper, zinc, copper/zinc ratio, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia. Perinatoloji Dergisi 2015;23(3):S72 DOI: 10.2399/prn.15.S001084

Yazar Bilgileri

Murat Bakacak¹,

Salih Serin²,

Metin Kılınç¹,

Fazıl Avcı³,

Önder Ercan¹,

Bülent Köstü¹,

Hakan Kıran¹,

Gürkan Kıran¹

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Kahramanmaraş
Tatvan Devlet Hastanesi, Bitlis
Patnos Devlet Hastanesi, Ağrı

Yayın Geçmişi

Gönderilme Tarihi: 30 Ağustos 2015

Son Revizyon Tarihi: 30 Ağustos 2015

Kabul Edilme Tarihi: 01 Eylül 2015

Erken Baskı Tarihi: 01 Ekim 2015

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Amaç

Preeclampsia (PE) is a hypertensive disorder of pregnancy which is estimated to occur in 2% to 8% of pregnancies. Numerous studies have investigated the aetiology and pathophysiology of preeclampsia. However, the pathophysiology of preeclampsia remains poorly understood. The aim of the current study was to determine the levels of MDA and SOD, concentrations of Cu, Zn and the Cu/Zn ratio in pregnant females with and without PE and in non-pregnant females of reproductive age to investigate a possible correlation between these parameters and foetal birth weight.

Yöntem

Forty-two non-pregnant women (NP), 40 healthy pregnant women (HP) and 38 pre-eclamptic pregnant (PE) women were included in this study. Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), Cu and Zn and Cu/Zn ratios were studied in these cases. In addition, correlations of the serum levels of Cu, Zn, MDA, SOD and Cu/Zn rate with foetal birth weights were examined.

Bulgular

Cu, MDA levels and Cu/Zn ratio were significantly higher in the PE group than in the HP and NP groups, and significantly higher in the HP than in the NP group (p<.001 and p<.001; respectively). Serum Zn and SOD levels were significantly lower in the PE group compared with those in the HP and NP groups, and significantly lower in the HP than in the NP group (p<.001 and p<.001; respectively). When a possible correlation was investigated between the serum levels of Cu, Zn, MDA, SOD and Cu/Zn ratio, a statistically significant negative correlation was found only between increased rates of Cu/Zn and foetal birth weight in the PE group (r=-0.433, p<.001).

Sonuç

Increased lipid peroxidation and an impaired antioxidant defence mechanism as well as the concentration of trace elements such as Cu and Zn, and a possible correlation between those parameters may be associated at least partly with the pathogenesis of pre-eclampsia. In addition, the Cu/Zn ratio may be a parameter which can be used in the prediction of vascular complications of PE.