Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum. Perinatoloji Dergisi 2015;23(3):S73
- Dicle Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilimdalı, Diyarbakır
- Diyarbakır Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Diyarbakır
- Fırat Üniversitesi Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Elazığ
Senem Yaman Tunç, Dicle Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilimdalı, Diyarbakır, firstname.lastname@example.org
Gönderilme Tarihi: 30 Ağustos 2015
Son Revizyon Tarihi: 30 Ağustos 2015
Kabul Edilme Tarihi: 01 Eylül 2015
Erken Baskı Tarihi: 01 Ekim 2015
Yayınlanma Tarihi: 01 Ekim 2015
Çıkar çakışması bulunmadığı belirtilmiştir.
To investigate whether serum levels of neopterin, inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and oxidative status indicators were altered in patients with hyperemesis gravidarum (HG).
This cross-sectional study was performed on 30 pregnants with HG (mean age: 30.67±6.68) and 30 controls (mean age: 28.00±5.30). Demographic features, obstetric history, the Pregnancy Unique Quantification of Emesis/Nausea (PUQE) index were noted. Complete blood count, serum biochemical assay as well as measurement of levels of CRP, TNF-a, IL-6, total antioxidant status (TAS) and total oxidative status (TOS) were implemented. Groups were compared in terms of these parameters and whether there are any correlations between these parameters.
White blood cell count (p=0.013), platelet count (p=0.015), TOS (p<0.001), PUQE score (p<0.001) and frequency of positivity for urinary ketone bodies (p<0.001) were remarkably higher in HG. On the other hand, serum levels of lactate dehydrogenase, (p<0.001), sodium (p<0.001), potassium (p<0.001), chloride (p<0.001) and TAS (p<0.001) were higher in the control group. No difference was noted with respect to levels of neopterin, CRP, TNF-a and IL-6. In patients with HG, positive correlation was detected between TOS and serum levels of LDH, while TNF-a, IL-6 and neopterin were positively correlated with haemoglobin levels.
Our results reveal that oxidative stress and inflammation may be associated with HG. Elucidation of the pathophysiology and complex interaction between various inflammatory processes necessitates further trials on larger series.