Urınary no levels are decreased in preeclampsia. Perinatoloji Dergisi 1999;7(2):110-110
- Inonu University School of Medicine Departments of Biochemistry Malatya TR
- Inonu University School of Medicine Departments of Obstetrics and Gynecology Malatya TR
Çıkar çakışması bulunmadığı belirtilmiştir.
Nitric oxide (NO) is a potent vascular endothelial cell derived vasorelaxant with important effects on vascular tone. It was aimed to assess maternal blood and urine nitric oxide (NO) levels and serum uric acid concentration in preeclampsia.
Thirty preclamptic and thirty-one healty women with singleton pregnancy were studied in the third trimester. Maternal venous blood and 24 hour urıne were collected from all subjects prior to birth. Serum and urine nitric oxide levels were determined with the greiss reaction by measuring combined oxidation products of nitric oxide, serum nitrite and nitrate after reduction with nitrate reductase. Independent t test was used for statistical significance. p<0.05 was set for significance.
Patients ages and gestational weeks were not different in both groups (p>0.05). There was no difference in maternal serum nitric oxide levels between groups (preeclamptic group 46,9±8,8 umol/L, control group 41,2±14,6umol/L, p>0.05). Urine levels were significantly lower in preclamptic group (preeclamptic group 365,5±41,9umol/L, control group 719,1±80,2umol/L p<001). Serum uric acid concentration was higher in preeclampsia groups (preeclamptic group 6,83±1,65 mg/dl, control group 4,58±1,17 mgl/dl) significantly (p<0.01). Decreased NO and creatinin clearens were observed (preeclamptic group 8,1±1,5 ml/dk vs 19,2±6,2 ml/dk, control group 85,5±25,9 ml/dk vs 122,0±19,5 ml/dk respectively, p<0.01).
Circulating levels of nitrite in preeclampsia are not different from healty pregnant women in the third trimester. But urine levels of nitrite is significantly lower in preeclampsia. Also serum uric acid levels were markedly elevated in preeclamptic group and always accompanied with decreased urine NO levels. These data suggest that renal clearence of NO may have a direct role in NO metabolism in preeclampsia. Decreased NO and creatinin clearence should be due to the effect of preeclampsia on the renal function in those patients.