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Dergi Kimliği

Online ISSN
1305-3132

Kuruluş
1993

Editor-in-Chief
​Cihat Şen, ​Nicola Volpe

Editors
Daniel Rolnik, Mar Gil, Murat Yayla, Oluş Api

Antioxidant enzyme activıties in erythrocytes in maternal and fetal circulation in preeclampsia

Mustafa Çekmen, Yusuf Turkoz, Remzi Gökdeniz

Künye

Antioxidant enzyme activıties in erythrocytes in maternal and fetal circulation in preeclampsia. Perinatoloji Dergisi 1999;7(2):111-111

Yazar Bilgileri

Mustafa Çekmen1,
Yusuf Turkoz1,
Remzi Gökdeniz2

  1. Inonu University School of Medicine Department of Biochemistry Malatya TR
  2. Inonu University School of Medicine Department of Obstetrics and Gynecology Malatya TR
Yazışma Adresi

Remzi Gökdeniz, Inonu University School of Medicine Department of Obstetrics and Gynecology Malatya TR,

Yayın Geçmişi
Çıkar Çakışması

Çıkar çakışması bulunmadığı belirtilmiştir.

Giriş

Free radical induced lipid peroxidation has been suggested as a possible pathogenic factor of preeclampsia. It was aimed to measure antioxidant enzyme activity in erythrocytes in maternal and fetal circulation in preeclamptic patients in the third trimester.

Yöntem

Maternal and umblical venous blood were obtained from thirty preeclamptic and thirty-one normotensif women with singletton pregnancy in the third trimester. The activities of glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD) were determined.

Bulgular

Patients ages and gestational weeks were not different in both groups (p>0.05). Whilst GSH-Px (U/gHb) and SOD-(U/gHb) were significantly higher (1857±131,2 vs 1387±123,8 and 2593,2±330.7 vs 2041±200,3, p<0.01), CAT (K/gHb) was significantly lower (71,2±18.1 vs 137,3±27,1) in erythrocyte of patients with preeclampsia and of controls (P<0.01). In umblical erythrocytes, SOD was significantly higher (1818.5±151.5 vs 1535.8±169.2, p<0.01) respectively, whereas CAT and GSH-Px were not different (84.8±14.3 vs 97.1±31.8 and 1207.5±117.5 vs 1211.41103.7, p>0.05). Independent t test was used for statistical significance. p<0.05 was set for significance.

Sonuç

These results demonstrate that increase in oxidative stress in preeclampsia results in development of defence mechanism both in maternal and fetal circulation to protect against reactive oxygen species. CAT has no impact on this protective effect in preeclampsia.
Anahtar Kelimeler

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