Lıpıd peroxıdatıon ın cord blood at bırth: The effects of breech delıvery. Perinatoloji Dergisi 1999;7(2):178-178
Çıkar çakışması bulunmadığı belirtilmiştir.
The purpose of this study was to determine oxygen free radical activity in breech presentation at birth and relate it to umbilical cord blood acid-base status. DESIGN: A series of 63 singleton deliveries (28 cephalic deliveries (controls), 23 breech deliveries with normoacidemia, and 12 breech deliveries with mild acidemia) had determination of malondialdehyde and acid-base parameters. SETTTNG: Delivery suite in the Department of Obstetrics and Gynaecology at Süleyman Demirel University, İsparta, Turkey.
POPULATION: 63 singleton term deliveries, spontaneous or induced labour and initially normal fetal heart rate tracing.
After delivery, umbilical cord arterial and venous blood samples were collected for determination of malondialdehyde. Oxygen saturation, PO2, PCO2, pH, and base excess (BE) were also measured.
MAIN OUTCOME MEASURES: Umbilical cord arterial and venous bloods gases and malondialdehyde levels.
There was a significant correlation between umbilical arterial and venous levels of malondialdehyde and all acid-base parameters (p<0.001). it has been found that there were negative correlations between malondialdehyde and pH, PO2 and bicarbonate while there was a positive correlation between malondialdehyde and PCO2. A positive correlation between malondialdehyde and base excess was present in the control group and total breech group (n=35). The malondialdehyde levels in the total breech group, nonacidemic breech group(n=23) and mildacidemic breech group (n=12) were significantly higher than those in the control group (p<0.0001). However, acid-base parameters in the nonacidemic breech group were not statistically different from those in the control group.
Lipid peroxidation products (malondialdehyde) were found to exist to some extent in the umbilical cords of newborns with normal acid-base parameters in breech delivery. Our data support the contention that lipid peroxide may be a more appropriate outcome measure than acid-base balance.