Amaç
The purpose of this study was to determine the concentrations of the following cytokines: interleukin-1alpha (IL-1alpha), interleukin 1-beta (IL-1beta), interlukin 6 (IL-6), and interleukin 8 (IL-8) in vaginal fluid of pregnant women in relation to infection of genital mycoplasmas.
Yöntem
Samples of vaginal fluid were collected from 40 pregnant women. The cytokines concentrations (pg/mL) were measured by Standard enzyme-linked immunosorbent assay technique (ELISA).
Bulgular
Among 15 women genital mycoplasmas infections was diagnosed. Vaginal levels of interleukin-1alpha, interlekin-1beta, and interleukin- 6 vvere found to be significant elevated in women with mycoplasmas infection (127,11 pg/mL; 56,14 pg/mL; 22,08 pg/mL) as compared with patients without infection (76,16 pg/mL; 32,87 pg/mL; 15,13 pg/mL).
Sonuç
These findings suggest that measurement of cervicovaginal concentrations of selected cytokines may constitute a clinically useful marker of genital mycoplasmas infection. Relation between cytokines levels and risk of perinatal complications should be evaluated in further studies.
Anahtar Kelimeler
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